The circadian clock circuitry modulates leukemia initiating cell activity in T-cell acute lymphoblastic leukemia

The circadian clock circuitry modulates leukemia initiating cell activity in T-cell acute lymphoblastic leukemia

Abstract Background T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy, characterized by restricted cellular subsets with asymmetrically enriched leukemia initiating cell (LIC) activity. Nonetheless, it is still unclear which signaling programs promote LIC maintena...

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Bibliographic Details
Main Authors: Emanuele Murgo, Elisabetta De Santis, Francesca Sansico, Valentina Melocchi, Tommaso Colangelo, Costanzo Padovano, Mattia Colucci, Annalucia Carbone, Beatrice Totti, Alireza Basti, Lisa Gottschlich, Angela Relogio, Nazzareno Capitanio, Fabrizio Bianchi, Gianluigi Mazzoccoli, Vincenzo Giambra
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
T-ALL
Circadian
Biological clock
IL20R
STAT3
Flow cytometry
Online Access:https://doi.org/10.1186/s13046-023-02799-7

Internet

https://doi.org/10.1186/s13046-023-02799-7

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