RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes

RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes

Here the authors propose an RNA interference-based switch for dynamic control of AAV transgene expression. In this approach, transgene expression may be silenced by RNAi and subsequently recovered using REVERSIR oligonucleotides.

Bibliographic Details
Main Authors: Megha Subramanian, James McIninch, Ivan Zlatev, Mark K. Schlegel, Charalambos Kaittanis, Tuyen Nguyen, Saket Agarwal, Timothy Racie, Martha Arbaiza Alvarado, Kelly Wassarman, Thomas S. Collins, Tyler Chickering, Christopher R. Brown, Karyn Schmidt, Adam B. Castoreno, Svetlana Shulga-Morskaya, Elena Stamenova, Kira Buckowing, Daniel Berman, Joseph D. Barry, Anna Bisbe, Martin A. Maier, Kevin Fitzgerald, Vasant Jadhav
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37774-5

Internet

https://doi.org/10.1038/s41467-023-37774-5

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