RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes
Here the authors propose an RNA interference-based switch for dynamic control of AAV transgene expression. In this approach, transgene expression may be silenced by RNAi and subsequently recovered using REVERSIR oligonucleotides.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37774-5 |
| _version_ | 1827970412956352512 |
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| author | Megha Subramanian James McIninch Ivan Zlatev Mark K. Schlegel Charalambos Kaittanis Tuyen Nguyen Saket Agarwal Timothy Racie Martha Arbaiza Alvarado Kelly Wassarman Thomas S. Collins Tyler Chickering Christopher R. Brown Karyn Schmidt Adam B. Castoreno Svetlana Shulga-Morskaya Elena Stamenova Kira Buckowing Daniel Berman Joseph D. Barry Anna Bisbe Martin A. Maier Kevin Fitzgerald Vasant Jadhav |
| author_facet | Megha Subramanian James McIninch Ivan Zlatev Mark K. Schlegel Charalambos Kaittanis Tuyen Nguyen Saket Agarwal Timothy Racie Martha Arbaiza Alvarado Kelly Wassarman Thomas S. Collins Tyler Chickering Christopher R. Brown Karyn Schmidt Adam B. Castoreno Svetlana Shulga-Morskaya Elena Stamenova Kira Buckowing Daniel Berman Joseph D. Barry Anna Bisbe Martin A. Maier Kevin Fitzgerald Vasant Jadhav |
| author_sort | Megha Subramanian |
| collection | DOAJ |
| description | Here the authors propose an RNA interference-based switch for dynamic control of AAV transgene expression. In this approach, transgene expression may be silenced by RNAi and subsequently recovered using REVERSIR oligonucleotides. |
| first_indexed | 2024-04-09T18:52:22Z |
| format | Article |
| id | doaj.art-0fc8fb8623c24daabbd0601f2495d2bc |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T18:52:22Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0fc8fb8623c24daabbd0601f2495d2bc2023-04-09T11:20:32ZengNature PortfolioNature Communications2041-17232023-04-0114111210.1038/s41467-023-37774-5RNAi-mediated rheostat for dynamic control of AAV-delivered transgenesMegha Subramanian0James McIninch1Ivan Zlatev2Mark K. Schlegel3Charalambos Kaittanis4Tuyen Nguyen5Saket Agarwal6Timothy Racie7Martha Arbaiza Alvarado8Kelly Wassarman9Thomas S. Collins10Tyler Chickering11Christopher R. Brown12Karyn Schmidt13Adam B. Castoreno14Svetlana Shulga-Morskaya15Elena Stamenova16Kira Buckowing17Daniel Berman18Joseph D. Barry19Anna Bisbe20Martin A. Maier21Kevin Fitzgerald22Vasant Jadhav23Alnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsAlnylam PharmaceuticalsHere the authors propose an RNA interference-based switch for dynamic control of AAV transgene expression. In this approach, transgene expression may be silenced by RNAi and subsequently recovered using REVERSIR oligonucleotides.https://doi.org/10.1038/s41467-023-37774-5 |
| spellingShingle | Megha Subramanian James McIninch Ivan Zlatev Mark K. Schlegel Charalambos Kaittanis Tuyen Nguyen Saket Agarwal Timothy Racie Martha Arbaiza Alvarado Kelly Wassarman Thomas S. Collins Tyler Chickering Christopher R. Brown Karyn Schmidt Adam B. Castoreno Svetlana Shulga-Morskaya Elena Stamenova Kira Buckowing Daniel Berman Joseph D. Barry Anna Bisbe Martin A. Maier Kevin Fitzgerald Vasant Jadhav RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes Nature Communications |
| title | RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes |
| title_full | RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes |
| title_fullStr | RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes |
| title_full_unstemmed | RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes |
| title_short | RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes |
| title_sort | rnai mediated rheostat for dynamic control of aav delivered transgenes |
| url | https://doi.org/10.1038/s41467-023-37774-5 |
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