Hepatic Encephalopathy-Associated Cerebral Vasculopathy in Acute-on-Chronic Liver Failure: Alterations on Endothelial Factor Release and Influence on Cerebrovascular Function

Hepatic Encephalopathy-Associated Cerebral Vasculopathy in Acute-on-Chronic Liver Failure: Alterations on Endothelial Factor Release and Influence on Cerebrovascular Function

The acute-on-chronic liver failure (ACLF) is a syndrome characterized by liver decompensation, hepatic encephalopathy (HE) and high mortality. We aimed to determine the mechanisms implicated in the development of HE-associated cerebral vasculopathy in a microsurgical liver cholestasis (MHC) model of...

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Bibliographic Details
Main Authors: Laura Caracuel, Esther Sastre, María Callejo, Raquel Rodrigues-Díez, Ana B. García-Redondo, Isabel Prieto, Carlos Nieto, Mercedes Salaices, Ma Ángeles Aller, Jaime Arias, Javier Blanco-Rivero
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Physiology
Subjects:
acute-on-chronic liver failure
hepatic encephalopathy
cerebral vasculature
bradykinin
nitric oxide
prostaglandin I2
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.593371/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.593371/full

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