Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice

Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice

Objective: The hypothalamus regulates feeding and glucose homeostasis through the balanced action of different neuropeptides, which are cleaved and activated by the proprotein convertases PC1/3 and PC2. However, the recent association of polymorphisms in the proprotein convertase FURIN with type 2 d...

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Bibliographic Details
Main Authors: Ilaria Coppola, Bas Brouwers, Leanne Walker, Ceyhun Alar, Sandra Meulemans, Anne White, Bruno Ramos-Molina, John W.M. Creemers
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Metabolism
Subjects:
FURIN
POMC
proACTH
ACTH
Hypothalamus
Obesity
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782200196X

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http://www.sciencedirect.com/science/article/pii/S221287782200196X

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