Influence of promoter polymorphisms of the TNF-α (-308G/A) and IL-6 (-174G/C) genes on therapeutic response to etanercept in rheumatoid arthritis

Influence of promoter polymorphisms of the TNF-α (-308G/A) and IL-6 (-174G/C) genes on therapeutic response to etanercept in rheumatoid arthritis

Background: The study was undertaken to assess the influence of functional -308G /A TNF-α (rs 1800629) and -174G/C IL-6 (rs1800795) promoter polymorphisms on the therapeutic response to etanercept, a TNF-α blocker, in patients with rheumatoid arthritis (RA). Methods: Seventy-three patients suffering...

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Bibliographic Details
Main Authors: Jančić Ivan, Šefik-Bukilica Mirjana, Živojinović Slađana, Damjanov Nemanja, Spasovski Vesna, Kotur Nikola, Klaassen Kristel, Pavlović Sonja, Bufan Biljana, Arsenović-Ranin Nevena
Format: Article
Language:English
Published: Society of Medical Biochemists of Serbia, Belgrade 2015-01-01
Series:Journal of Medical Biochemistry
Subjects:
etanercept
pharmacogenetics
rheumatoid arthritis
308g/a tnf-α gene polymorphism
174g/c il-6 gene polymorphism
Online Access:https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2015/1452-82581504414J.pdf

Internet

https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2015/1452-82581504414J.pdf

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