Opposing Roles of DCs and iNKT Cells in the Induction of Foxp3 Expression by MLN CD25<sup>+</sup>CD4<sup>+</sup> T Cells during IFNγ-Driven Colitis

Opposing Roles of DCs and iNKT Cells in the Induction of Foxp3 Expression by MLN CD25<sup>+</sup>CD4<sup>+</sup> T Cells during IFNγ-Driven Colitis

We have previously shown that a deficiency of CD1d-restricted invariant natural killer T (iNKT) cells exacerbates dextran sulfate sodium (DSS)-induced colitis in Yeti mice that exhibit IFNγ-mediated hyper-inflammation. Although iNKT cell-deficiency resulted in reduced Foxp3 expression by mesenteric...

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Bibliographic Details
Main Authors: Sung Won Lee, Hyun Jung Park, Luc Van Kaer, Seokmann Hong
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
iNKT cells
IFNγ
Treg cells
dendritic cells
CD25<sup>+</sup>CD4<sup>+</sup> T cells
Online Access:https://www.mdpi.com/1422-0067/23/23/15316

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https://www.mdpi.com/1422-0067/23/23/15316

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