An Arginine-Rich Motif in the ORF2 capsid protein regulates the hepatitis E virus lifecycle and interactions with the host cell.

Hepatitis E virus (HEV) infection is the most common cause of acute viral hepatitis worldwide. Hepatitis E is usually asymptomatic and self-limiting but it can become chronic in immunocompromised patients and is associated with increased fulminant hepatic failure and mortality rates in pregnant wome...

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Main Authors: Kévin Hervouet, Martin Ferrié, Maliki Ankavay, Claire Montpellier, Charline Camuzet, Virginie Alexandre, Aïcha Dembélé, Cécile Lecoeur, Arnold Thomas Foe, Peggy Bouquet, David Hot, Thibaut Vausselin, Jean-Michel Saliou, Sophie Salomé-Desnoulez, Alexandre Vandeputte, Laurent Marsollier, Priscille Brodin, Marlène Dreux, Yves Rouillé, Jean Dubuisson, Cécile-Marie Aliouat-Denis, Laurence Cocquerel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010798