Clinical Implications of Human Population Differences in Genome-wide Rates of Functional Genotypes

Clinical Implications of Human Population Differences in Genome-wide Rates of Functional Genotypes

There have been a number of recent successes in the use of whole genome sequencing and sophisticated bioinformatics techniques to identify pathogenic DNA sequence variants responsible for individual idiopathic congenital conditions. However, the success of this identification process is heavily infl...

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Bibliographic Details
Main Authors: Ali eTorkamani, Phillip ePham, Ondrej eLibiger, Vikas eBansal, Guangfa eZhang, Ashley A Scott-Van Zeeland, Ryan eTewhey, Eric J. Topol, Nicholas eSchork
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Genetics
Subjects:
Genomics
Population Genetics
diversity
Human Disease
functional variant
variant annotation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00211/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00211/full

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