Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer

Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer

Abstract Background N6-methyladenosine (m6A) modification is the most abundant reversible methylation modification in eukaryotes, and it is reportedly closely associated with a variety of cancers progression, including colorectal cancer (CRC). This study showed that activated lipid metabolism and gl...

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Bibliographic Details
Main Authors: Mujie Ye, Jinhao Chen, Feiyu Lu, Minghui Zhao, Suwen Wu, Chunhua Hu, Ping Yu, Jingbao Kan, Jianan Bai, Ye Tian, Qiyun Tang
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Cell & Bioscience
Subjects:
Colorectal cancer
N6-methyladenosine
RNA demethylase
Glycolysis
Online Access:https://doi.org/10.1186/s13578-023-01100-9

Internet

https://doi.org/10.1186/s13578-023-01100-9

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