Circulating memory PD-1+CD8+ T cells and PD-1+CD8+T/PD-1+CD4+T cell ratio predict response and outcome to immunotherapy in advanced gastric cancer patients

Circulating memory PD-1+CD8+ T cells and PD-1+CD8+T/PD-1+CD4+T cell ratio predict response and outcome to immunotherapy in advanced gastric cancer patients

Abstract Background Limited benefit population of immunotherapy makes it urgent to select effective biomarkers for screening appropriate treatment population. Herein, we have investigated the predictive values of circulating CD8+ T cells and CD8+T/CD4+T cell ratio in advanced gastric cancer patients...

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Bibliographic Details
Main Authors: Jiang Liu, Degan Liu, Guangyin Hu, Jingjing Wang, Dadong Chen, Chuanjun Song, Yin Cai, Chentong Zhai, Wenjing Xu
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cancer Cell International
Subjects:
Gastric cancer
Immunotherapy
Immune checkpoint inhibitors
Memory CD8+ T cells
CD8+T/CD4+T cell ratio
Predictive biomarkers
Online Access:https://doi.org/10.1186/s12935-023-03137-9

Internet

https://doi.org/10.1186/s12935-023-03137-9

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