Gradual Increase of FcγRIIIa/CD16a Expression and Shift toward IFN-γ Secretion during Differentiation of CD56dim Natural Killer Cells

Gradual Increase of FcγRIIIa/CD16a Expression and Shift toward IFN-γ Secretion during Differentiation of CD56dim Natural Killer Cells

Natural killer (NK) cell effector functions include cytotoxicity and secretion of cytokines such as interferon-γ (IFN-γ). The immature CD56bright subset of human NK cells lacks expression of FcγRIIIa/CD16a, one of the low-affinity immunoglobulin G receptors, or exhibits low-density expression (CD56b...

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Bibliographic Details
Main Authors: Laurie Lajoie, Nicolas Congy-Jolivet, Armelle Bolzec, Gilles Thibault
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
CD56dim natural killer cells
FcγRIIIa/CD16a
degranulation
IFN-γ
killer Ig-like receptors
NKG2A
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01556/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01556/full

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