Acacetin inhibits inflammation by blocking MAPK/NF-κB pathways and NLRP3 inflammasome activation

Acacetin inhibits inflammation by blocking MAPK/NF-κB pathways and NLRP3 inflammasome activation

Objective: Our preliminary research indicates that acacetin modulates the nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing 3 (NLRP3) inflammasome, providing protection against Alzheimer’s Disease (AD) and cerebral ischemic reperfusion injury. The mechanisms of ac...

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Bibliographic Details
Main Authors: Juan Bu, Yeledan Mahan, Shengnan Zhang, Xuanxia Wu, Xiaoling Zhang, Ling Zhou, Yanmin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Pharmacology
Subjects:
inflammasome
NLRP3
acacetin
MAPK pathway
NF-κB pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1286546/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1286546/full

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