Neutral sphingomyelinase-3 mediates TNF-stimulated oxidant activity in skeletal muscle

Neutral sphingomyelinase-3 mediates TNF-stimulated oxidant activity in skeletal muscle

Aims: Sphingolipid and oxidant signaling affect glucose uptake, atrophy, and force production of skeletal muscle similarly and both are stimulated by tumor necrosis factor (TNF), suggesting a connection between systems. Sphingolipid signaling is initiated by neutral sphingomyelinase (nSMase), a fami...

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Bibliographic Details
Main Authors: Jennifer S. Moylan, Jeffrey D. Smith, Erin M. Wolf Horrell, Julie B. McLean, Gergana M. Deevska, Mark R. Bonnell, Mariana N. Nikolova-Karakashian, Michael B. Reid
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Sphingolipid signaling
Neutral sphingomyelinase-3
nSMase3
Skeletal muscle
Free radicals
Reactive oxygen species
ROS
Oxidants
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714000895

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http://www.sciencedirect.com/science/article/pii/S2213231714000895

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