Human CD8+ Tregs expressing a MHC-specific CAR display enhanced suppression of human skin rejection and GVHD in NSG mice

Human CD8+ Tregs expressing a MHC-specific CAR display enhanced suppression of human skin rejection and GVHD in NSG mice

Abstract: Polyclonal CD8+CD45RClow/− Tregs are potent regulatory cells able to control solid organ transplantation rejection and even induce tolerance. However, donor major histocompatibility complex (MHC)–specific Tregs are more potent than polyclonal Tregs in suppressing T-cell responses and preve...

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Main Authors: Séverine Bézie, Béatrice Charreau, Nadège Vimond, Juliette Lasselin, Nathalie Gérard, Véronique Nerrière-Daguin, Frédérique Bellier-Waast, Franck Duteille, Ignacio Anegon, Carole Guillonneau
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952920317523

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http://www.sciencedirect.com/science/article/pii/S2473952920317523

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