Role of mu opioid receptor (MOR) agonist efficacy as a determinant of opioid antinociception in a novel assay of pain-depressed behavior in female and male mice

Role of mu opioid receptor (MOR) agonist efficacy as a determinant of opioid antinociception in a novel assay of pain-depressed behavior in female and male mice

IntroductionIntermediate efficacy mu opioid receptor (MOR) agonists have potential to retain analgesic effectiveness while improving safety, but the optimal MOR efficacy for effective and safe opioid analgesia is unknown. Preclinical assays of pain-depressed behavior can assess effects of opioids an...

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Bibliographic Details
Main Authors: S. Stevens Negus, Hamid I. Akbarali, Minho Kang, Young K. Lee, Samuel A. Marsh, Edna J. Santos, Yan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Pain Research
Subjects:
efficacy
analgesia
pain-depressed behavior
mice
locomotor
mu opioid agonist
Online Access:https://www.frontiersin.org/articles/10.3389/fpain.2023.1281698/full

Internet

https://www.frontiersin.org/articles/10.3389/fpain.2023.1281698/full

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