MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling

MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling

Summary: Rett syndrome (RTT) is a severe neurological disorder, with impaired brain development caused by mutations in MECP2; however, the underlying mechanism remains elusive. We know from previous work that MeCP2 facilitates the processing of a specific microRNA, miR-199a, by associating with the...

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Bibliographic Details
Main Authors: Hideyuki Nakashima, Keita Tsujimura, Koichiro Irie, Takuya Imamura, Cleber A. Trujillo, Masataka Ishizu, Masahiro Uesaka, Miao Pan, Hirofumi Noguchi, Kanako Okada, Kei Aoyagi, Tomoko Andoh-Noda, Hideyuki Okano, Alysson R. Muotri, Kinichi Nakashima
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports
Subjects:
Rett syndrome
MeCP2
neural stem cell
differentiation
miR-199a
Smad
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721004630

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http://www.sciencedirect.com/science/article/pii/S2211124721004630

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