Dynamic modulation of thymidylate synthase gene expression and fluorouracil sensitivity in human colorectal cancer cells.

Biomarkers have revolutionized cancer chemotherapy. However, many biomarker candidates are still in debate. In addition to clinical studies, a priori experimental approaches are needed. Thymidylate synthase (TS) expression is a long-standing candidate as a biomarker for 5-fluorouracil (5-FU) treatme...

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Bibliographic Details
Main Authors: Kentaro Wakasa, Rumi Kawabata, Seiki Nakao, Hiroyoshi Hattori, Kenichi Taguchi, Junji Uchida, Takeharu Yamanaka, Yoshihiko Maehara, Masakazu Fukushima, Shinya Oda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4400010?pdf=render