Protective effect of secretory APE1/Ref‐1 on doxorubicin‐induced cardiotoxicity via suppression of ROS and p53 pathway

Protective effect of secretory APE1/Ref‐1 on doxorubicin‐induced cardiotoxicity via suppression of ROS and p53 pathway

Abstract Aims The clinical application of doxorubicin (DOX), a potent anthracycline anticancer drug that effectively treats various malignancies, is limited by its side effects, such as cardiomyopathy. Apurinic/apyrimidinic endonuclease 1/redox factor‐1 (APE1/Ref‐1) is a multifunctional protein that...

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Bibliographic Details
Main Authors: Soo Yeon An, Seon‐Ah Jin, Hee Jeong Seo, Yu Ran Lee, Sungmin Kim, Byeong Hwa Jeon, Jin‐Ok Jeong
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:ESC Heart Failure
Subjects:
Apurinic apyrimidinic endonuclease 1/redox factor‐1
Doxorubicin
Heart failure
p53 signalling pathway
Oxidative stress
Cardiomyopathy
Online Access:https://doi.org/10.1002/ehf2.14686

Internet

https://doi.org/10.1002/ehf2.14686

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