Protective effect of secretory APE1/Ref‐1 on doxorubicin‐induced cardiotoxicity via suppression of ROS and p53 pathway

Protective effect of secretory APE1/Ref‐1 on doxorubicin‐induced cardiotoxicity via suppression of ROS and p53 pathway

Abstract Aims The clinical application of doxorubicin (DOX), a potent anthracycline anticancer drug that effectively treats various malignancies, is limited by its side effects, such as cardiomyopathy. Apurinic/apyrimidinic endonuclease 1/redox factor‐1 (APE1/Ref‐1) is a multifunctional protein that...

Full description

Bibliographic Details
Main Authors:	Soo Yeon An, Seon‐Ah Jin, Hee Jeong Seo, Yu Ran Lee, Sungmin Kim, Byeong Hwa Jeon, Jin‐Ok Jeong
Format:	Article
Language:	English
Published:	Wiley 2024-04-01
Series:	ESC Heart Failure
Subjects:	Apurinic apyrimidinic endonuclease 1/redox factor‐1 Doxorubicin Heart failure p53 signalling pathway Oxidative stress Cardiomyopathy
Online Access:	https://doi.org/10.1002/ehf2.14686

Similar Items

Elevated APE1/Ref-1 Levels of Synovial Fluids in Patients with Rheumatoid Arthritis: Reflection of Disease Activity
by: In Seol Yoo, et al.
Published: (2021-11-01)

Inhibition of APE1/Ref-1 for Neovascular Eye Diseases: From Biology to Therapy
by: Gabriella D. Hartman, et al.
Published: (2021-09-01)

17<i>β</i>-Estradiol Increases APE1/Ref-1 Secretion in Vascular Endothelial Cells and Ovariectomized Mice: Involvement of Calcium-Dependent Exosome Pathway
by: Yu-Ran Lee, et al.
Published: (2021-08-01)

Molecular Mechanisms Regulating the DNA Repair Protein APE1: A Focus on Its Flexible N-Terminal Tail Domain
by: David J. López, et al.
Published: (2021-06-01)

α1-Adrenoceptor agonist methoxamine inhibits base excision repair via inhibition of apurinic/apyrimidinic endonuclease 1 (APE1)
by: Kohutova Aneta, et al.
Published: (2023-06-01)

APE1/Ref-1 as a Therapeutic Target for Inflammatory Bowel Disease
by: Lauren Sahakian, et al.
Published: (2023-10-01)

Comparative Analysis of Exo- and Endonuclease Activities of APE1-like Enzymes
by: Anastasiia T. Davletgildeeva, et al.
Published: (2022-03-01)

Elevated Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Effector Factor-1 Levels in Refractory Kawasaki Disease
by: Yu-Ran Lee, et al.
Published: (2022-01-01)

Cleavage of the APE1 N-Terminal Domain in Acute Myeloid Leukemia Cells Is Associated with Proteasomal Activity
by: Lisa Lirussi, et al.
Published: (2020-03-01)

The Enigma of Substrate Recognition and Catalytic Efficiency of APE1-Like Enzymes
by: Anastasiia T. Davletgildeeva, et al.
Published: (2021-03-01)

Impact of the APE1 Redox Function Inhibitor E3330 in Non-Small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion
by: Rita Manguinhas, et al.
Published: (2020-06-01)

The role of genotype/phenotype at apurinic/apyrimidinic endonuclease Rs1130409 in renal cell carcinoma
by: Cheng-Hsi Liao, et al.
Published: (2020-01-01)

Insights into Mechanisms of Damage Recognition and Catalysis by APE1-like Enzymes
by: Anatoly A. Bulygin, et al.
Published: (2022-04-01)

The Kinetic Mechanism of 3′-5′ Exonucleolytic Activity of AP Endonuclease Nfo from <i>E. coli</i>
by: Svetlana I. Senchurova, et al.
Published: (2022-09-01)

The Role of Active-Site Plasticity in Damaged-Nucleotide Recognition by Human Apurinic/Apyrimidinic Endonuclease APE1
by: Anatoly A. Bulygin, et al.
Published: (2020-08-01)

Chemical Inhibition of Apurinic-Apyrimidinic Endonuclease 1 Redox and DNA Repair Functions Affects the Inflammatory Response via Different but Overlapping Mechanisms
by: Thais Teixeira Oliveira, et al.
Published: (2021-09-01)

Inner Amino Acid Contacts Are Key Factors of Multistage Structural Rearrangements of DNA and Affect Substrate Specificity of Apurinic/Apyrimidinic Endonuclease APE1
by: Anatoly A. Bulygin, et al.
Published: (2023-07-01)

The regulatory role of APE1 in epithelial‐to‐mesenchymal transition and in determining EGFR‐TKI responsiveness in non‐small‐cell lung cancer
by: Xiao Yang, et al.
Published: (2018-09-01)

Antileukemic Efficacy in Vitro of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies
by: Vanessa Kohl, et al.
Published: (2019-10-01)

Serum Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) Level as a Potential Biomarker of Cholangiocarcinoma
by: Doungdean Tummanatsakun, et al.
Published: (2019-08-01)

The DNA Repair Enzyme Apurinic/Apyrimidinic Endonuclease (Apex Nuclease) 2 Has the Potential to Protect against Down-Regulation of Chondrocyte Activity in Osteoarthritis
by: Naoko Yui, et al.
Published: (2014-08-01)

A DNA/RNA hybrid fluorescent probe for high-throughput quantification of the activity of human apurinic/apyrimidinic endonuclease 1 in subcellular extracts
by: Peng Lu, et al.
Published: (2023-09-01)

Common Kinetic Mechanism of Abasic Site Recognition by Structurally Different Apurinic/Apyrimidinic Endonucleases
by: Alexandra A. Kuznetsova, et al.
Published: (2021-08-01)

Apurinic/Apyrimidinic Endonuclease 1 and Tyrosyl-DNA Phosphodiesterase 1 Prevent Suicidal Covalent DNA-Protein Crosslink at Apurinic/Apyrimidinic Site
by: Natalia A. Lebedeva, et al.
Published: (2021-01-01)

The Impact of Human DNA Glycosylases on the Activity of DNA Polymerase β toward Various Base Excision Repair Intermediates
by: Artemiy S. Bakman, et al.
Published: (2023-05-01)

Apurinic/apyrimidinic endonuclease 1 performs multiple roles in controlling the outcome of cancer cells toward radiation and chemotherapeutic agents
by: Dindial Ramotar, et al.
Published: (2018-01-01)

Visualization and Comparison of the Level of Apurinic/Apyrimidinic Endonuclease 1 in Live Normal/Cancerous and Neuron Cells with a Fluorescent Nanoprobe
by: Peng Lu, et al.
Published: (2023-05-01)

Alteration of AP-endonuclease1 expression in curcumin-treated fibrotic rats
by: Ahmad R. Bassiouny, et al.
Published: (2011-10-01)

The role of endothelin-1 in the doxorubicin cardiotoxicity
by: Lilia Tacu
Published: (2020-10-01)

Plasma APE1/Ref-1 Correlates with Atherosclerotic Inflammation in ApoE<sup>−/−</sup> Mice
by: Yu Ran Lee, et al.
Published: (2020-09-01)

Chronological Age and DNA Damage Accumulation in Blood Mononuclear Cells: A Linear Association in Healthy Humans after 50 Years of Age
by: Nikolaos I. Vlachogiannis, et al.
Published: (2023-04-01)

Leucine zipper protein 1 prevents doxorubicin-induced cardiotoxicity in mice
by: Di Fan, et al.
Published: (2023-08-01)

Isorhapontigenin protects against doxorubicin-induced cardiotoxicity via increasing YAP1 expression
by: Panxia Wang, et al.
Published: (2021-03-01)

Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2
by: Jie Wang(a), et al.
Published: (2022-06-01)

Neuraminidase1 Inhibitor Protects Against Doxorubicin-Induced Cardiotoxicity via Suppressing Drp1-Dependent Mitophagy
by: Yating Qin, et al.
Published: (2021-12-01)

Tanshinone IIA Restores Dynamic Balance of Autophagosome/Autolysosome in Doxorubicin-Induced Cardiotoxicity via Targeting Beclin1/LAMP1
by: Xiaoping Wang, et al.
Published: (2019-06-01)

Resveratrol and FGF1 Synergistically Ameliorates Doxorubicin-Induced Cardiotoxicity via Activation of SIRT1-NRF2 Pathway
by: Guangping Lu, et al.
Published: (2022-09-01)

Resolvin D1 Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Inflammation, Oxidative and Endoplasmic Reticulum Stress
by: Menglong Wang, et al.
Published: (2022-01-01)

Meteorin-like protein attenuates doxorubicin-induced cardiotoxicity via activating cAMP/PKA/SIRT1 pathway
by: Can Hu, et al.
Published: (2020-10-01)

DiOHF Protects Against Doxorubicin-Induced Cardiotoxicity Through ERK1 Signaling Pathway
by: Danqi Chang, et al.
Published: (2019-09-01)