Thrombospondin 1 enhances systemic inflammation and disease severity in acute-on-chronic liver failure

Thrombospondin 1 enhances systemic inflammation and disease severity in acute-on-chronic liver failure

Abstract Background The key role of thrombospondin 1 (THBS1) in the pathogenesis of acute-on-chronic liver failure (ACLF) is unclear. Here, we present a transcriptome approach to evaluate THBS1 as a potential biomarker in ACLF disease pathogenesis. Methods Biobanked peripheral blood mononuclear cell...

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Bibliographic Details
Main Authors: Hozeifa Mohamed Hassan, Xi Liang, Jiaojiao Xin, Yingyan Lu, Qun Cai, Dongyan Shi, Keke Ren, Jun Li, Qi Chen, Jiang Li, Peng Li, Beibei Guo, Hui Yang, Jinjin Luo, Heng Yao, Xingping Zhou, Wen Hu, Jing Jiang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Medicine
Subjects:
Acute-on-chronic liver failure
Thrombospondin 1
Immune-metabolism disorder
Severity prediction
Inflammatory response
Hepatocellular apoptosis
Online Access:https://doi.org/10.1186/s12916-024-03318-x

Internet

https://doi.org/10.1186/s12916-024-03318-x

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