Deficiency in intestinal epithelial O‐GlcNAcylation predisposes to gut inflammation

Deficiency in intestinal epithelial O‐GlcNAcylation predisposes to gut inflammation

Abstract Post‐translational modifications in intestinal epithelial cells (IECs) allow for precise control in intestinal homeostasis, the breakdown of which may precipitate the pathological damage and inflammation in inflammatory bowel disease. The O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) modificati...

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Bibliographic Details
Main Authors: Ming Zhao, Xiwen Xiong, Kaiqun Ren, Bing Xu, Meng Cheng, Chinmayi Sahu, Kaichun Wu, Yongzhan Nie, Zan Huang, Richard S Blumberg, Xiaonan Han, Hai‐Bin Ruan
Format: Article
Language:English
Published: Springer Nature 2018-06-01
Series:EMBO Molecular Medicine
Subjects:
epithelial barrier function
gut microbiota
inflammatory bowel disease
Paneth cells
STAT signaling
Online Access:https://doi.org/10.15252/emmm.201708736

Internet

https://doi.org/10.15252/emmm.201708736

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