A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue

A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue

Objective: Type 2 diabetes mellitus (T2DM) is a common chronic metabolic disease. Peroxisome proliferator-activated receptors (PPARs) play crucial roles in regulating glucolipid metabolism. Previous studies showed that E17241 could ameliorate atherosclerosis and lower fasting blood glucose levels in...

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Bibliographic Details
Main Authors: Ren Sheng, Yining Li, Yexiang Wu, Chang Liu, Weizhi Wang, Xiaowan Han, Yinghong Li, Lijuan Lei, Xinhai Jiang, Yuyan Zhang, Yuhao Zhang, Shunwang Li, Bin Hong, Chao Liu, Yanni Xu, Shuyi Si
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
T2DM
Diabetic dyslipidemia
Pan-PPAR agonist
ABCA1
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222400101X

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http://www.sciencedirect.com/science/article/pii/S075333222400101X

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