G-CSF upregulates the expression of aquaporin-9 through CEBPB to enhance the cytotoxic activity of arsenic trioxide to acute myeloid leukemia cells

G-CSF upregulates the expression of aquaporin-9 through CEBPB to enhance the cytotoxic activity of arsenic trioxide to acute myeloid leukemia cells

Abstract Background Arsenic trioxide (ATO) is highly effective in acute promyelocytic leukemia (APL) patients, but it fails to show satisfactory efficacy in other acute myeloid leukemia (AML) patients with non-APL subtypes. Different from the APL cells, most non-APL AML cells express low levels of t...

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Bibliographic Details
Main Authors: Wanbin Fu, Gelan Zhu, Lan Xu, Jia Liu, Xiaofeng Han, Junying Wang, Xinpeng Wang, Jian Hou, Huanbin Zhao, Hua Zhong
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Cancer Cell International
Subjects:
Acute myeloid leukemia
Arsenic trioxide
G-CSF
AQP9
CEBPB
Online Access:https://doi.org/10.1186/s12935-022-02613-y

Internet

https://doi.org/10.1186/s12935-022-02613-y

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