Downregulation of YAP Activity Restricts P53 Hyperactivation to Promote Cell Survival in Confinement

Downregulation of YAP Activity Restricts P53 Hyperactivation to Promote Cell Survival in Confinement

Abstract Cell migration through confining three dimensional (3D) topographies can lead to loss of nuclear envelope integrity, DNA damage, and genomic instability. Despite these detrimental phenomena, cells transiently exposed to confinement do not usually die. Whether this is also true for cells sub...

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Bibliographic Details
Main Authors: Farnaz Hemmati, Ayuba Akinpelu, Jiyeon Song, Farshad Amiri, Anya McDaniel, Collins McMurray, Alexandros Afthinos, Stelios T. Andreadis, Andrew V. Aitken, Vinicia C. Biancardi, Sharon Gerecht, Panagiotis Mistriotis
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Advanced Science
Subjects:
3D confinement
apoptosis
cell mechanosensing
cell migration
P53
YAP
Online Access:https://doi.org/10.1002/advs.202302228

Internet

https://doi.org/10.1002/advs.202302228

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