Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells

Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells

Chronic hyperglycemia impairs insulin secretion from pancreatic beta cells in diabetes. Here, the authors reveal that a glucose metabolite is responsible and show lowering glucose metabolism during hyperglycemia prevents loss of beta-cell function.

Bibliographic Details
Main Authors: Elizabeth Haythorne, Matthew Lloyd, John Walsby-Tickle, Andrei I. Tarasov, Jonas Sandbrink, Idoia Portillo, Raul Terron Exposito, Gregor Sachse, Malgorzata Cyranka, Maria Rohm, Patrik Rorsman, James McCullagh, Frances M. Ashcroft
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34095-x

Internet

https://doi.org/10.1038/s41467-022-34095-x

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