Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells
Chronic hyperglycemia impairs insulin secretion from pancreatic beta cells in diabetes. Here, the authors reveal that a glucose metabolite is responsible and show lowering glucose metabolism during hyperglycemia prevents loss of beta-cell function.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34095-x |
| _version_ | 1811309225493659648 |
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| author | Elizabeth Haythorne Matthew Lloyd John Walsby-Tickle Andrei I. Tarasov Jonas Sandbrink Idoia Portillo Raul Terron Exposito Gregor Sachse Malgorzata Cyranka Maria Rohm Patrik Rorsman James McCullagh Frances M. Ashcroft |
| author_facet | Elizabeth Haythorne Matthew Lloyd John Walsby-Tickle Andrei I. Tarasov Jonas Sandbrink Idoia Portillo Raul Terron Exposito Gregor Sachse Malgorzata Cyranka Maria Rohm Patrik Rorsman James McCullagh Frances M. Ashcroft |
| author_sort | Elizabeth Haythorne |
| collection | DOAJ |
| description | Chronic hyperglycemia impairs insulin secretion from pancreatic beta cells in diabetes. Here, the authors reveal that a glucose metabolite is responsible and show lowering glucose metabolism during hyperglycemia prevents loss of beta-cell function. |
| first_indexed | 2024-04-13T09:38:30Z |
| format | Article |
| id | doaj.art-0ffc4770f495445c90f47a4eeab0f02b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T09:38:30Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0ffc4770f495445c90f47a4eeab0f02b2022-12-22T02:52:01ZengNature PortfolioNature Communications2041-17232022-11-0113111910.1038/s41467-022-34095-xAltered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cellsElizabeth Haythorne0Matthew Lloyd1John Walsby-Tickle2Andrei I. Tarasov3Jonas Sandbrink4Idoia Portillo5Raul Terron Exposito6Gregor Sachse7Malgorzata Cyranka8Maria Rohm9Patrik Rorsman10James McCullagh11Frances M. Ashcroft12Department of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks RoadDepartment of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks RoadChemistry Research Laboratory, Department of Chemistry, University of OxfordSchool of Biomedical Sciences, Ulster UniversityDepartment of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks RoadDepartment of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks RoadDepartment of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks RoadDepartment of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks RoadDepartment of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks RoadDepartment of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks RoadOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill HospitalChemistry Research Laboratory, Department of Chemistry, University of OxfordDepartment of Physiology, Anatomy and Genetics and OXION, University of Oxford, Parks RoadChronic hyperglycemia impairs insulin secretion from pancreatic beta cells in diabetes. Here, the authors reveal that a glucose metabolite is responsible and show lowering glucose metabolism during hyperglycemia prevents loss of beta-cell function.https://doi.org/10.1038/s41467-022-34095-x |
| spellingShingle | Elizabeth Haythorne Matthew Lloyd John Walsby-Tickle Andrei I. Tarasov Jonas Sandbrink Idoia Portillo Raul Terron Exposito Gregor Sachse Malgorzata Cyranka Maria Rohm Patrik Rorsman James McCullagh Frances M. Ashcroft Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells Nature Communications |
| title | Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells |
| title_full | Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells |
| title_fullStr | Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells |
| title_full_unstemmed | Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells |
| title_short | Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells |
| title_sort | altered glycolysis triggers impaired mitochondrial metabolism and mtorc1 activation in diabetic β cells |
| url | https://doi.org/10.1038/s41467-022-34095-x |
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