Glucose controls co-translation of structurally related mRNAs via the mTOR and eIF2 pathways in human pancreatic beta cells

Glucose controls co-translation of structurally related mRNAs via the mTOR and eIF2 pathways in human pancreatic beta cells

Pancreatic beta cell response to glucose is critical for the maintenance of normoglycemia. A strong transcriptional response was classically described in rodent models but, interestingly, not in human cells. In this study, we exposed human pancreatic beta cells to an increased concentration of gluco...

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Bibliographic Details
Main Authors: Manuel Bulfoni, Costas Bouyioukos, Albatoul Zakaria, Fabienne Nigon, Roberta Rapone, Laurence Del Maestro, Slimane Ait-Si-Ali, Raphaël Scharfmann, Bertrand Cosson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Endocrinology
Subjects:
response to glucose
mRNA feature
translation regulation
Human beta cells
RNA co-regulation
mTOR
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.949097/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.949097/full

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