BRCA1 Promoter Hypermethylation in Malignant Breast Tumors and in the Histologically Normal Adjacent Tissues to the Tumors: Exploring Its Potential as a Biomarker and Its Clinical Significance in a Translational Approach

BRCA1 Promoter Hypermethylation in Malignant Breast Tumors and in the Histologically Normal Adjacent Tissues to the Tumors: Exploring Its Potential as a Biomarker and Its Clinical Significance in a Translational Approach

The hypermethylation status of the promoter region of the breast cancer 1 (<i>BRCA1)</i>, a well-known tumor suppressor gene, has been extensively investigated in the last two decades as a potential biomarker for breast cancer. In this retrospective study, we investigated the prevalence...

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Bibliographic Details
Main Authors: Yassire Oubaddou, Mohamed Oukabli, Salma Fenniche, Abderrahim Elktaibi, Mohamed Reda Elochi, Abderrahmane Al Bouzidi, Zineb Qmichou, Nadia Dakka, Caroline Diorio, Antje Richter, Youssef Bakri, Rabii Ameziane El Hassani
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Genes
Subjects:
BRCA1 promoter hypermethylation
breast cancers
normal adjacent tissue
benign breast lesions
methylation-specific PCR
biomarker
Online Access:https://www.mdpi.com/2073-4425/14/9/1680

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https://www.mdpi.com/2073-4425/14/9/1680

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