p16: cycling off the beaten path
p16INK4A (hereafter called p16) is a faithful cellular ally in the fight against tumorigenesis. Although its canonical pathway through retinoblastoma (RB) is well delineated, RB-independent functions for p16 are beginning to emerge. Here we summarize non-canonical roles of p16, including our recent...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-11-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2019.1677140 |
| _version_ | 1797677126185385984 |
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| author | Raquel Buj Katherine M. Aird |
| author_facet | Raquel Buj Katherine M. Aird |
| author_sort | Raquel Buj |
| collection | DOAJ |
| description | p16INK4A (hereafter called p16) is a faithful cellular ally in the fight against tumorigenesis. Although its canonical pathway through retinoblastoma (RB) is well delineated, RB-independent functions for p16 are beginning to emerge. Here we summarize non-canonical roles of p16, including our recent finding on its role in nucleotide metabolism. |
| first_indexed | 2024-03-11T22:40:27Z |
| format | Article |
| id | doaj.art-0ffed3b61ae74d3dbb26bcba0e6ae2db |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:27Z |
| publishDate | 2019-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-0ffed3b61ae74d3dbb26bcba0e6ae2db2023-09-22T09:11:01ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562019-11-016610.1080/23723556.2019.16771401677140p16: cycling off the beaten pathRaquel Buj0Katherine M. Aird1Penn State College of MedicinePenn State College of Medicinep16INK4A (hereafter called p16) is a faithful cellular ally in the fight against tumorigenesis. Although its canonical pathway through retinoblastoma (RB) is well delineated, RB-independent functions for p16 are beginning to emerge. Here we summarize non-canonical roles of p16, including our recent finding on its role in nucleotide metabolism.http://dx.doi.org/10.1080/23723556.2019.1677140retinoblastomacell cyclesenescencenucleotide metabolismmtorc1reactive oxygen speciesnf-κbjnk1/3sp1ap-1 |
| spellingShingle | Raquel Buj Katherine M. Aird p16: cycling off the beaten path Molecular & Cellular Oncology retinoblastoma cell cycle senescence nucleotide metabolism mtorc1 reactive oxygen species nf-κb jnk1/3 sp1 ap-1 |
| title | p16: cycling off the beaten path |
| title_full | p16: cycling off the beaten path |
| title_fullStr | p16: cycling off the beaten path |
| title_full_unstemmed | p16: cycling off the beaten path |
| title_short | p16: cycling off the beaten path |
| title_sort | p16 cycling off the beaten path |
| topic | retinoblastoma cell cycle senescence nucleotide metabolism mtorc1 reactive oxygen species nf-κb jnk1/3 sp1 ap-1 |
| url | http://dx.doi.org/10.1080/23723556.2019.1677140 |
| work_keys_str_mv | AT raquelbuj p16cyclingoffthebeatenpath AT katherinemaird p16cyclingoffthebeatenpath |