L-glutamic acid-g-poly hydroxyethyl methacrylate nanoparticles: acute and sub-acute toxicity and biodistribution potential in mice

L-glutamic acid-g-poly hydroxyethyl methacrylate nanoparticles: acute and sub-acute toxicity and biodistribution potential in mice

The aim of this safety study in mice was to determine in vivo toxicity and biodistribution potential of a single and multiple doses of L-glutamic acid-g-p(HEMA) polymeric nanoparticles as a drug delivery system. The single dose did not cause any lethal effect, and its acute oral LD50 was >2.000 m...

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Bibliographic Details
Main Authors: Bakan Buket, Oltulu Fatih, Yıldırım Yeliz, Yavaşoğlu Altuğ, Akgöl Sinan, Karabay Yavaşoğlu Nefise Ülkü
Format: Article
Language:English
Published: Sciendo 2023-09-01
Series:Arhiv za Higijenu Rada i Toksikologiju
Subjects:
biocompatibility
blood biochemistry
genotoxicity
histology
in vivo toxicity
micronucleus test
polymers
biokompatibilnost
biokemija krvi
genotoksičnost
histologija
in vivo toksičnost
mikronukleus test
polimeri
Online Access:https://doi.org/10.2478/aiht-2023-74-3768

Internet

https://doi.org/10.2478/aiht-2023-74-3768

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