Hepcidin Upregulation in Colorectal Cancer Associates with Accumulation of Regulatory Macrophages and Epithelial–Mesenchymal Transition and Correlates with Progression of the Disease

Hepcidin Upregulation in Colorectal Cancer Associates with Accumulation of Regulatory Macrophages and Epithelial–Mesenchymal Transition and Correlates with Progression of the Disease

Advanced, metastatic colorectal cancer (CRC) is associated with high rate of mortality because of its poor responsiveness to chemotherapy/immunotherapy. Recent studies have shown that hepcidin, a peptide hormone produced mainly by hepatocytes, is expressed by and enhances the growth of tumor cells....

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Bibliographic Details
Main Authors: Antonio Di Grazia, Davide Di Fusco, Eleonora Franzè, Marco Colella, Georgios Strimpakos, Silvia Salvatori, Vincenzo Formica, Federica Laudisi, Claudia Maresca, Alfredo Colantoni, Angela Ortenzi, Carmine Stolfi, Ivan Monteleone, Giovanni Monteleone
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
type 2 macrophages
cancer metastasis
prognosis
Stat3
cytokines
Online Access:https://www.mdpi.com/2072-6694/14/21/5294

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https://www.mdpi.com/2072-6694/14/21/5294

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