High-Throughput Screening for Bacterial Glycosyltransferase Inhibitors

High-Throughput Screening for Bacterial Glycosyltransferase Inhibitors

The enteropathogenic and enterohemorrhagic Escherichia coli NleB proteins as well as the Salmonella enterica SseK proteins are type III secretion system effectors that function as glycosyltransferase enzymes to post-translationally modify host substrates on arginine residues. This modification is un...

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Bibliographic Details
Main Authors: Samir El Qaidi, Congrui Zhu, Peter McDonald, Anuradha Roy, Pradip Kumar Maity, Digamber Rane, Chamani Perera, Philip R. Hardwidge
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
bacterial pathogenesis
glycosylteransferase
innate immnuity
signal transduction
virulence
type III secreted effector protein
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00435/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2018.00435/full

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