Comprehensive review on neprilysin (NEP) inhibitors: design, structure-activity relationships, and clinical applications

Comprehensive review on neprilysin (NEP) inhibitors: design, structure-activity relationships, and clinical applications

Neprilysin (NEP), a zinc-dependent membrane-bound metallopeptidase, regulates various bioactive peptides, particularly in kidneys, vascular endothelium, and the central nervous system. NEP’s involvement in metabolizing natriuretic peptides, insulin, and enkephalins makes it a promising target for tr...

Full description

Bibliographic Details
Main Authors: Xinyue Zhang, Chun Hu, Erkang Tian, Yanxin Shen, Wei Liu, Juan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
neprilysin
NEP inhibitor
structure-activity relationship
drug design
clinical
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1501407/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1501407/full

Similar Items