Remdesivir inhibits the progression of glioblastoma by enhancing endoplasmic reticulum stress

Remdesivir inhibits the progression of glioblastoma by enhancing endoplasmic reticulum stress

Glioblastoma (GBM) is one of the most aggressive primary malignant brain tumors. The major challenge is the lack of effective therapeutic drugs due to the blood–brain barrier (BBB) and tumor heterogeneity. Remdesivir (RDV), a new member of the nucleotide analog family, has previously been shown to h...

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Bibliographic Details
Main Authors: Yujia Chen, Yuduo Guo, Shenglun Li, Jiacheng Xu, Weihai Ning, Chao Zhao, Jun Wang, Yanming Qu, Mingshan Zhang, Wanlu Zhou, Qinghua Cui, Hongwei Zhang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Glioblastoma
Remdesivir
Endoplasmic reticulum stress
PERK-mediated unfolded protein response
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222014263

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http://www.sciencedirect.com/science/article/pii/S0753332222014263

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