Adoptive immunotherapy with Cl-IB-MECA-treated CD8+ T cells reduces melanoma growth in mice.

Adoptive immunotherapy with Cl-IB-MECA-treated CD8+ T cells reduces melanoma growth in mice.

Cl-IB-MECA is a selective A3 adenosine receptor agonist, which plays a crucial role in limiting tumor progression. In mice, Cl-IB-MECA administration enhances the anti-tumor T cell-mediated response. However, little is known about the activity of Cl-IB-MECA on CD8+ T cells. The aim of this study was...

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Bibliographic Details
Main Authors: Antonella Montinaro, Giovanni Forte, Rosalinda Sorrentino, Antonio Luciano, Giuseppe Palma, Claudio Arra, Ian M Adcock, Aldo Pinto, Silvana Morello
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3454429?pdf=render

Internet

http://europepmc.org/articles/PMC3454429?pdf=render

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