Under expression of the Sonic Hedgehog receptor, Patched1 (PTCH1), is associated with an increased risk of local recurrence in squamous cell carcinoma of the vulva arising on a background of Lichen Sclerosus.

Under expression of the Sonic Hedgehog receptor, Patched1 (PTCH1), is associated with an increased risk of local recurrence in squamous cell carcinoma of the vulva arising on a background of Lichen Sclerosus.

OBJECTIVE:Dysregulation of the Hedgehog (Hh) pathway has been described in a variety of cancers, including cervical cancer, a disease which shares a common aetiology with vulval squamous cell carcinoma (VSCC). Here, we investigate a large number of primary VSCC cases for evidence of Hedgehog pathway...

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Bibliographic Details
Main Authors: Jason Yap, Richard Fox, Natalie Narsia, Sonia Pinheiro-Maia, Rachel Pounds, Ciaran Woodman, David Luesley, Raji Ganesan, Sean Kehoe, Christopher Dawson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6209322?pdf=render

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http://europepmc.org/articles/PMC6209322?pdf=render

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