Azithromycin Mitigates Cisplatin-Induced Lung Oxidative Stress, Inflammation and Necroptosis by Upregulating SIRT1, PPARγ, and Nrf2/HO-1 Signaling

Azithromycin Mitigates Cisplatin-Induced Lung Oxidative Stress, Inflammation and Necroptosis by Upregulating SIRT1, PPARγ, and Nrf2/HO-1 Signaling

Acute lung injury (ALI) is one of the adverse effects of the antineoplastic agent cisplatin (CIS). Oxidative stress, inflammation, and necroptosis are linked to the emergence of lung injury in various disorders. This study evaluated the effect of the macrolide antibiotic azithromycin (AZM) on oxidat...

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Bibliographic Details
Main Authors: Emad H. M. Hassanein, Ghadir A. Sayed, Abdullah M. Alzoghaibi, Abdalmohsen S. Alammar, Basel A. Abdel-Wahab, Omnia A. M. Abd El-Ghafar, Somya E. Mahdi, Ahmed M. Atwa, Mohammed A. Alzoghaibi, Ayman M. Mahmoud
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pharmaceuticals
Subjects:
chemotherapy
necroptosis
lung injury
oxidative stress
cisplatin
inflammation
Online Access:https://www.mdpi.com/1424-8247/16/1/52

Internet

https://www.mdpi.com/1424-8247/16/1/52

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