Candesartan Attenuates Cisplatin-Induced Lung Injury by Modulating Oxidative Stress, Inflammation, and TLR-4/NF-κB, JAK1/STAT3, and Nrf2/HO-1 Signaling

Candesartan Attenuates Cisplatin-Induced Lung Injury by Modulating Oxidative Stress, Inflammation, and TLR-4/NF-κB, JAK1/STAT3, and Nrf2/HO-1 Signaling

Cisplatin (CIS) is an effective chemotherapeutic agent against different cancers. The use of CIS is associated with acute lung injury (ALI) and other adverse effects, and oxidative stress and inflammation were implicated in its toxic effects. Candesartan (CAN), an angiotensin II (Ang II) receptor bl...

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Bibliographic Details
Main Authors: Ahmed M. Atwa, Omnia A. M. Abd El-Ghafar, Emad H. M. Hassanein, Somya E. Mahdi, Ghadir A. Sayed, Reem S. Alruhaimi, Haifa A. Alqhtani, Mohammed F. Alotaibi, Ayman M. Mahmoud
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceuticals
Subjects:
chemotherapy
candesartan
lung injury
oxidative stress
inflammation
Online Access:https://www.mdpi.com/1424-8247/15/10/1222

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https://www.mdpi.com/1424-8247/15/10/1222

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