Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation

Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation

Abstract WNT signaling is fundamental in development and homeostasis, but how the Frizzled receptors (FZDs) propagate signaling remains enigmatic. Here, we present the cryo-EM structure of FZD4 engaged with the DEP domain of Dishevelled 2 (DVL2), a key WNT transducer. We uncover a distinct binding m...

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Bibliographic Details
Main Authors: Yu Qian, Zhengxiong Ma, Zhenmei Xu, Yaning Duan, Yangjie Xiong, Ruixue Xia, Xinyan Zhu, Zongwei Zhang, Xinyu Tian, Han Yin, Jian Liu, Jing Song, Yang Lu, Anqi Zhang, Changyou Guo, Lihua Jin, Woo Jae Kim, Jiyuan Ke, Fei Xu, Zhiwei Huang, Yuanzheng He
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-52174-z

Internet

https://doi.org/10.1038/s41467-024-52174-z

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