Gender differences in vascular expression of endothelin and ET A/ET B receptors, but not in calcium handling mechanisms, in deoxycorticosterone acetate-salt hypertension

Gender differences in vascular expression of endothelin and ET A/ET B receptors, but not in calcium handling mechanisms, in deoxycorticosterone acetate-salt hypertension

We determined if the increased vascular responsiveness to endothelin-1 (ET-1) observed in male, but not in female, DOCA-salt rats is associated with differential vascular mRNA expression of ET-1 and/or ET A/ET B receptors or with functional differences in Ca2+ handling mechanisms by vascular myocyte...

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Bibliographic Details
Main Authors: F.L. David, A.C.I. Montezano, N.A. Rebouças, D. Nigro, Z.B. Fortes, M.H.C. Carvalho, R.C.A. Tostes
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2002-09-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
DOCA-salt hypertension
Endothelin-1
Gender
Endothelin receptors
Calcium
Rats
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000900006&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000900006&tlng=en

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