Sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoids

Sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoids

Summary: Human immunodeficiency virus type-1 (HIV-1)-associated neurocognitive disorder (HAND) affects up to half of people living with HIV-1 and causes long term neurological consequences. The pathophysiology of HIV-1-induced glial and neuronal functional deficits in humans remains enigmatic. To br...

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Bibliographic Details
Main Authors: Andrew J. Boreland, Alessandro C. Stillitano, Hsin-Ching Lin, Yara Abbo, Ronald P. Hart, Peng Jiang, Zhiping P. Pang, Arnold B. Rabson
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:iScience
Subjects:
Molecular biology
Neuroscience
Immunology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224008502

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http://www.sciencedirect.com/science/article/pii/S2589004224008502

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