Bruton’s Tyrosine Kinase (BTK) Inhibitor RN486 Overcomes ABCB1-Mediated Multidrug Resistance in Cancer Cells

Bruton’s Tyrosine Kinase (BTK) Inhibitor RN486 Overcomes ABCB1-Mediated Multidrug Resistance in Cancer Cells

Overexpression of ATP-binding cassette subfamily B member 1 (ABCB1) remains one of the most vital factors leading to multidrug resistance (MDR). It is important to enhance the effect and bioavailability of chemotherapeutic drugs that are substrates of ABCB1 transporter in ABCB1-overexpression cancer...

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Bibliographic Details
Main Authors: Xing-Duo Dong, Meng Zhang, Xiubin Ma, Jing-Quan Wang, Zi-Ning Lei, Qiu-Xu Teng, Yi-Dong Li, Lusheng Lin, Weiguo Feng, Zhe-Sheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
RN486
Bruton’s tyrosine kinase inhibitor
multidrug resistance
ATP-binding cassette transporter
ABCB1
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00865/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00865/full

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