Eupatilin Improves Cilia Defects in Human CEP290 Ciliopathy Models

Eupatilin Improves Cilia Defects in Human CEP290 Ciliopathy Models

The photoreceptor outer segment is a highly specialized primary cilium that is essential for phototransduction and vision. Biallelic pathogenic variants in the cilia-associated gene <i>CEP290</i> cause non-syndromic Leber congenital amaurosis 10 (LCA10) and syndromic diseases, where the...

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Bibliographic Details
Main Authors: Julio C. Corral-Serrano, Paul E. Sladen, Daniele Ottaviani, Olivia F. Rezek, Dimitra Athanasiou, Katarina Jovanovic, Jacqueline van der Spuy, Brian C. Mansfield, Michael E. Cheetham
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
CEP290
Leber congenital amaurosis (LCA)
retina
ciliopathy
photoreceptor
cilium
Online Access:https://www.mdpi.com/2073-4409/12/12/1575

Internet

https://www.mdpi.com/2073-4409/12/12/1575

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