Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice

Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice

Background and aims: Atherosclerosis is an important cause of clinical cardiovascular events. Atherosclerotic plaques are hypoxic, and reoxygenation improves plaque phenotype. Central players in hypoxia are hypoxia inducible factors (HIF) and their regulators, HIF-prolyl hydroxylase (PHD) isoforms 1...

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Váldodahkkit: Jasper A. F. Demandt, Kim van Kuijk, Thomas L. Theelen, Elke Marsch, Sean P. Heffron, Edward A. Fisher, Peter Carmeliet, Erik A. L. Biessen, Judith C. Sluimer
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Frontiers Media S.A. 2021-05-01
Ráidu:Frontiers in Cell and Developmental Biology
Fáttát:
atherosclerosis
triglycerides
prolyl hydroxylase domain protein
hematocrit
hypoxia
Liŋkkat:https://www.frontiersin.org/articles/10.3389/fcell.2021.664258/full

Interneahtta

https://www.frontiersin.org/articles/10.3389/fcell.2021.664258/full

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