A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers.

All tissue development and replenishment relies upon the breaking of symmetries leading to the morphological and operational differentiation of progenitor cells into more specialized cells. One of the main engines driving this process is the Notch signal transduction pathway, a ubiquitous signalling...

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Bibliographic Details
Main Authors: Daipeng Chen, Zary Forghany, Xinxin Liu, Haijiang Wang, Roeland M H Merks, David A Baker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1010169