Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release

<p>Abstract</p> <p>Background</p> <p>Apoptosis plays a key role in cell death observed in neurodegenerative diseases marked by a progressive loss of neurons as seen in Alzheimer's disease. Although the exact cause of apoptosis is not known, a number of factors such...

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Bibliographic Details
Main Authors: Zhang YueMei, Bhavnani Bhagu R
Format: Article
Language:English
Published: BMC 2005-02-01
Series:BMC Neuroscience
Online Access:http://www.biomedcentral.com/1471-2202/6/13