TORC1 inactivation promotes APC/C-dependent mitotic slippage in yeast and human cells

Summary: Unsatisfied kinetochore-microtubule attachment activates the spindle assembly checkpoint to inhibit the metaphase-anaphase transition. However, some cells eventually override mitotic arrest by mitotic slippage. Here, we show that inactivation of TORC1 kinase elicits mitotic slippage in budd...

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Bibliographic Details
Main Authors: Chihiro Yamada, Aya Morooka, Seira Miyazaki, Masayoshi Nagai, Satoru Mase, Kenji Iemura, Most Naoshia Tasnin, Tsuneyuki Takuma, Shotaro Nakamura, Shamsul Morshed, Naoki Koike, Md. Golam Mostofa, Muhammad Arifur Rahman, Tasnuva Sharmin, Haruko Katsuta, Kotaro Ohara, Kozo Tanaka, Takashi Ushimaru
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422101645X