Effect of Ketamine on Human Neurochemistry in Posterior Cingulate Cortex: A Pilot Magnetic Resonance Spectroscopy Study at 3 Tesla

Effect of Ketamine on Human Neurochemistry in Posterior Cingulate Cortex: A Pilot Magnetic Resonance Spectroscopy Study at 3 Tesla

Ketamine is a powerful glutamatergic long-lasting antidepressant, efficient in intractable major depression. Whereas ketamine’s immediate psychomimetic side-effects were linked to glutamate changes, proton MRS (1H-MRS) showed an association between the ratio of glutamate and glutamine and delayed an...

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Bibliographic Details
Main Authors: Petr Bednarik, Benjamin Spurny, Leo R. Silberbauer, Alena Svatkova, Patricia A. Handschuh, Birgit Reiter, Melisande E. Konadu, Thomas Stimpfl, Marie Spies, Wolfgang Bogner, Rupert Lanzenberger
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Neuroscience
Subjects:
ketamine
glutamate
glutamine
magnetic resonance spectroscopy
depression
ketamine metabolites
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.609485/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.609485/full

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