OSMAC-Based Discovery and Biosynthetic Gene Clusters Analysis of Secondary Metabolites from Marine-Derived <i>Streptomyces globisporus</i> SCSIO LCY30

OSMAC-Based Discovery and Biosynthetic Gene Clusters Analysis of Secondary Metabolites from Marine-Derived <i>Streptomyces globisporus</i> SCSIO LCY30

The one strain many compounds (OSMAC) strategy is an effective method for activating silent gene clusters by cultivating microorganisms under various conditions. The whole genome sequence of the marine-derived strain<i> Streptomyces globisporus</i> SCSIO LCY30 revealed that it contains 3...

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Bibliographic Details
Main Authors: Yanqing Li, Naying Gong, Le Zhou, Zhijie Yang, Hua Zhang, Yucheng Gu, Junying Ma, Jianhua Ju
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Marine Drugs
Subjects:
OSMAC
biosynthetic gene clusters (BGCs)
angucyclines
streptophenazines
tumor cytotoxic activity
Online Access:https://www.mdpi.com/1660-3397/22/1/21

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https://www.mdpi.com/1660-3397/22/1/21

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